Antiserum to brain gangliosides produces recurrent epileptiform activity

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Science  12 Nov 1976:
Vol. 194, Issue 4266, pp. 735-737
DOI: 10.1126/science.982041


A single injection of 10 microliters of antiserum to total brain ganglioside onto (and into) the sensorimotor cortex of the rat resulted in recurrent spiking in the cortical electroencephalogram, lasting from 7 to 17 days. Absorption of antibody with pure monosialoganglioside (GM1) completely abosished the effect. Spiking was reactivated after 4 weeks by intramuscular injection of pentylenetetrazole.