Early eye removal produces excessive bilateral branching in the rat: application of cobalt filling method

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Science  19 Nov 1976:
Vol. 194, Issue 4267, pp. 857-859
DOI: 10.1126/science.982050


When one eye of a rat is removed at birth, axons from the remaining eye form an excess of branches which are directed to both sides of the brain. This finding, which is based on a novel application of cobalt tracing methods, provides an explanation for previous reports of expanded uncrossed projections after early eye removal.