Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets

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Science  24 Dec 1976:
Vol. 194, Issue 4272, pp. 1421-1423
DOI: 10.1126/science.795030


D-Glucose, but not L-glucose or 3-O-methyl-D-glucose, stimulates 45Ca2+ uptake by both lanthanum-displaceable and lanthanum-nondisplaceable pools in pancreatic islets. The nondisplaceable pool probably represents secretory granules, while the displaceable pool may be located in the beta-cell membrane. Kinetic studies with isotopically labeled islets suggest that only the displaceable pool participates in the short-term coupling of the glucose stimulus with secretion.