HLA antigens and corticosteroid response

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Science  24 Dec 1976:
Vol. 194, Issue 4272, pp. 1427-1428
DOI: 10.1126/science.1006308


Compared with normal individuals, patients with primary open-angle glaucoma have increased prevalences of HLA-B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA-B12 antigen require significantly (P less than .02) lower concentrations of prednisolone to inhibit phytohemagglutinin-induced transformation.