Infidelity of DNA synthesis in vitro: screening for potential metal mutagens or carcinogens

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Science  24 Dec 1976:
Vol. 194, Issue 4272, pp. 1434-1436
DOI: 10.1126/science.1006310


Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.