Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas

See allHide authors and affiliations

Science  07 Jan 1977:
Vol. 195, Issue 4273, pp. 68-70
DOI: 10.1126/science.137524


Complete reversal of streptozotocin-induced diabetes mellitus in adult rats will follow transplantation of a single fetal pancreas if the organ is first grown in a normal syngeneic carrier before transfer to the diabetic recipient. Careful control of the blood sugar of diabetic recipients may enhance the function of a single donor organ and thus improve histocompatibility matching.