Reports

Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens

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Science  07 Jan 1977:
Vol. 195, Issue 4273, pp. 80-81
DOI: 10.1126/science.831259

Abstract

The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.