Antimetabolic extract from the brain of the hibernating ground squirrel Citellus tridecemlineatus

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Science  07 Jan 1977:
Vol. 195, Issue 4273, pp. 84-85
DOI: 10.1126/science.831261


Extracts of subcortical brains from hibernating ground squirrels, when injected intravenously into rats, caused a mean decrease in oxygen consumption of 35 percent and a decline in body temperature of 5 degree C. The effects lasted from 75 minutes to 30 hours. Brain extracts of nonhibernating squirrels caused no significant changes in these parameters.