Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor

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Science  14 Jan 1977:
Vol. 195, Issue 4274, pp. 181-183
DOI: 10.1126/science.188134


Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37 degree C, but not at 4 degree C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.