Reports

Does "blastocyst estrogen" initiate implantation?

Science  18 Feb 1977:
Vol. 195, Issue 4279, pp. 687-688
DOI: 10.1126/science.841306

Abstract

Fertilized eggs were incubated for 2 hours in a medium containing estradiol-17beta and then transferred into the uteri of day 5 pseudopregnant rats. These eggs, but not estrogen-free control eggs, induced a local increase in capillary permeability. We suggest that the blastocyst factor which induces the local increase in capillary permeability during early pregnancy is estrogen synthesized by the blastocyst.

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