Regeneration of oligodendroglia during recovery from demyelinating disease

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Science  18 Feb 1977:
Vol. 195, Issue 4279, pp. 693-694
DOI: 10.1126/science.190678


Infection of mice with the JHM strain of mouse hepatitis virus causes demyelination as a result of a cytolytic infection of oligodendroglia. In recovery, animals show remyelination, which could result either from surviving oligodendrocytes extending their territory or by generation of new oligodendroglia. Electron microscopic autoradiographic studies with 3H-labeled thymidine demonstrate that the cells associated with remyelination are newly generated oligodendroglia.