Reports

Possible cyclic nucleotide regulation of calcium mediating myocardial contraction

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Science  11 Mar 1977:
Vol. 195, Issue 4282, pp. 982-990
DOI: 10.1126/science.14399

Abstract

An inhibitor of adenylate and guanylate cyclases was tested on strips of left atria from rabbits. Effects of catecholamines (cardiotonic) and of acetylcholine (cardiodepressive) were blocked, and positive force-frequency was converted to negative. Ouabain produced only contracture without positive inotropy. The cardiotonic effect of increased calcium remained. Data suggest that cyclic nucleotides modulate calcium associated with these stimuli.

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