Reduced warfarin binding of albumin variants

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Science  11 Mar 1977:
Vol. 195, Issue 4282, pp. 991-994
DOI: 10.1126/science.841323


Binding studies of albumins A/A and A/Me from human plasma and isolated albumin revealed small, but statistically significant, reductions in warfarin binding of albumin A/Me compared to albumin A/A. Such differences in binding in vitro could result in altered pharmacological responses to warfarin administered to individuals possessing albumin A/Me. To determine if clinically significant differences in warfarin distribution exist, observations should be made in vivo on patients of different albumin phenotype who are receiving warfarin therapeutically.