Neurophysin biosynthesis: conversion of a putative precursor during axonal transport

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Science  25 Mar 1977:
Vol. 195, Issue 4284, pp. 1354-1356
DOI: 10.1126/science.65791


[35S]Cysteine injected adjacent to the supraoptic nucleus of the rat is rapidly incorporated into a 20,000-dalton protein that, in time, is converted to a 12,000-dalton labeled protein, neurophysin. This putative precursor of neurophysin appears to be synthesized in the supraoptic nucleus and transformed to neurophysin and related peptides during axonal transport to the neurohypophysis.