Probability of establishing chimeric plasmids in natural populations of bacteria

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Science  08 Apr 1977:
Vol. 196, Issue 4286, pp. 218-220
DOI: 10.1126/science.847470


Formulas for estimating the probability that chimeric plasmids carried by disarmed hosts will become established in natural populations of bacteria are presented and their use illustrated with a series of realistic numerical examples. The implications of these a priori probability estimates for the problem of containment for recombinant DNA research is discussed.