Alzheimer's Disease, Trisomy 21, and Myeloproliferative Disorders: Associations Suggesting a Genetic Diathesis

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Science  15 Apr 1977:
Vol. 196, Issue 4287, pp. 322-323
DOI: 10.1126/science.196.4287.322


Relatives of probands with Alzheimer's disease had excessive incidences of trisomy 21 and myeloproliferative disorders. Microtubules are structures that are likely to be affected by a genetic defect causing a predisposition to Alzheimer's disease, trisomy 21 and, possibly, to myeloproliferative disorders.