Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

Science  15 Apr 1977:
Vol. 196, Issue 4287, pp. 326-328
DOI: 10.1126/science.847477


Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

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