Antigen-antibody reactions in rat brain sites induce transient changes in drinking behavior

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Science  15 Apr 1977:
Vol. 196, Issue 4287, pp. 328-330
DOI: 10.1126/science.191911


The septum or hypothalamus of rat brain was injected through implanted cannulas with antibody against membrane antigens in the rat brain or with antibody against exogenous soluble antigens (such as ovalbumin) followed by the specific antigen. Both immunological systems produced a moderate but highly significant decrease in drinking by thirsty rats. This phenomenon is suggested as an experimental model for behavioral disorders resulting from nondegenerative, immunological processes in the brain.