Major innervation of newborn rat cortex by monoaminergic neurons

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Science  22 Apr 1977:
Vol. 196, Issue 4288, pp. 444-447
DOI: 10.1126/science.850788


A major monoaminergic innervation in infant rat neocortex, predominantly in layer IV, has been demonstrated by ultrastructural and biochemical studies after the administration of exogenous catecholamine precursors and congeners. One-third of all cortical synapses have an uptake-storage mechanism for catecholamines. In newborn cortex, the storage capacity for catecholamines is tenfold greater than the endogenous levels, and the uptake-storage mechanism matures earlier than the ability to synthesize neurotransmitter.