Monosodium glutamate admlinistration to the newborn reduces reproductive ability in female and male mice

See allHide authors and affiliations

Science  22 Apr 1977:
Vol. 196, Issue 4288, pp. 452-454
DOI: 10.1126/science.557837


Monosodium glutamate (MSG) administered during the neonatal period (days 2 to 11) resulted in a sequence of events that were manifested in adulthood. Reproductive dysfunction was seen in both female and male animals. Females treated with MSG had fewer pregnancies and smaller litters, while males treated with MSG showed reduced fertility. The MSG-treated mice showed increased body weight and decreased pituitary, thyroid, ovary, or testis weights.