Covalent labeling of the tetrodotoxin receptor in excitable membranes

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Science  20 May 1977:
Vol. 196, Issue 4292, pp. 883-885
DOI: 10.1126/science.404708


A photoaffinity labeling technique is described by which a tetrodotoxin analog is covalently bound to receptor sites associated with the sodium pores of excitable membranes. The biological activity of the toxin analog is retained after the covalent binding reaction.