Mouse chromosome translocations: visualization and analysis by electron microscopy of the synaptonemal complex

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Science  20 May 1977:
Vol. 196, Issue 4292, pp. 892-894
DOI: 10.1126/science.870966

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Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is the pairing region of the X.