Evidence for abnormal heart induction in cardiac-mutant salamanders (Ambystoma mexicanum)

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Science  20 May 1977:
Vol. 196, Issue 4292, pp. 894-896
DOI: 10.1126/science.860120


Homozygosity for simple recessive gene c in axolotl embryos results in the absence of a heartbeat. Gene c alters the morphology of the mutant anterior endoderm - the primary heart inductor.