Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: a biochemical study

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Science  27 May 1977:
Vol. 196, Issue 4293, pp. 1001-1002
DOI: 10.1126/science.860126


Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin, These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.