Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis

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Science  27 May 1977:
Vol. 196, Issue 4293, pp. 1007-1009
DOI: 10.1126/science.860128


Scanning electron microscopy studies of spontaneously occurring atherosclerosis in pigeons reveal dramatic alterations in endothelial integrity. An irregular endothelium at the intimal cushion region of 5-week-old birds gives rise to extensive areas of pitted endothelium and subendothelial exposure. Thrombocytes, thrombocyte aggregates, and leukocytes are associated with the developing lesion.