Direct resorption of bone by human monocytes

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Science  03 Jun 1977:
Vol. 196, Issue 4294, pp. 1109-1111
DOI: 10.1126/science.16343


Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.