Stability of the individual globin genes during erythroid differentiation

Science  10 Jun 1977:
Vol. 196, Issue 4295, pp. 1213-1214
DOI: 10.1126/science.860136


The genes of sheep betaA, betaC, and gamma globin were all present in DNA from erythroid cells which synthesized only betaC globin. Similarly, selective excision of non-expressed genes was shown not to occur during human erythroid differentiation. In contrast, evolutionary deletion of the betaC gene accounts for the inability of many sheep to make this globin.