Naloxone in chronic schizophrenia

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Science  10 Jun 1977:
Vol. 196, Issue 4295, pp. 1227-1228
DOI: 10.1126/science.860138


The specific narcotic antagonist naloxone (0.4 milligram) was given intravenously to seven chronic schizophrenics who reported that they had very frequent auditory hallucinations. Saline solution was used as a placebo. The coded study did not reveal any effect of naloxone on hallucinations or on global psychopathology.