Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+

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Science  01 Jul 1977:
Vol. 197, Issue 4298, pp. 67-69
DOI: 10.1126/science.17160


The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2+ and Ba2+ increase release are not the same. Each ion appears to act selectively on a different process involved in transmitter release.