Circadian rhythm of synaptic excitability in rat and monkey central nervous system

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Science  01 Jul 1977:
Vol. 197, Issue 4298, pp. 91-92
DOI: 10.1126/science.194313


Synaptic responses in hippocampal granule cells to stimulation of their afferent fibers from the entorhinal cortex fluctuate with a 24-hour period. The phase of this cycle for rats and monkeys depends on whether the animal is naturally nocturnal or diurnal. In a rat blinded by enucleation, the rhythm persists but drifts out of phase with the rhythm of sighted controls.