Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid

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Science  15 Jul 1977:
Vol. 197, Issue 4300, pp. 282-285
DOI: 10.1126/science.195338


The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.