Goblet cells in embryonic intestine: accelerated differentiation in culture

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Science  22 Jul 1977:
Vol. 197, Issue 4301, pp. 368-370
DOI: 10.1126/science.560059


If duodenal tissue from 14-day chick embryos is cultured in chemically defined medium, more than twice as many goblet cells appear within 48 hours as in intact embryos during the same time. The increase in goblet cell number is further accelerated by 10(-9) molar thyroxine but is prevented by 10(-6) molar hydrocortisone. The results suggest that differentiation of intestinal epithelium is regulated in part by a circulating inhibitor.