L-dopa: selective toxicity for melanoma cells in vitro

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Science  29 Jul 1977:
Vol. 197, Issue 4302, pp. 468-469
DOI: 10.1126/science.877570


In a study of the effect of L-dopa, an intermediate in the biosynthesis of the pigment melanin, on the growth of human and murine melanoma cells a highly selective inhibition of growth was observed for pigmented cell lines (S91A and human melanoma) as compared to the nonpigmented control cells (amelanotic melanoma S91B, mouse fibroblast L929, and Chinese hamster ovary). There was a correlation between toxicity and the extent of incorporation of radioactively labeled L-dopa by each line.