Inhibition of a lymphocyte membrane enzyme by delta9-tetrahydrocannabinol in vitro

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Science  29 Jul 1977:
Vol. 197, Issue 4302, pp. 475-477
DOI: 10.1126/science.877571


Delta-9-tetrahydrocannabinol (delta9-THC) inhibited the activity of lysolecithin acyl transferase, a membrane-bound lymphocyte enzyme, at concentrations above 1.3 muM. Stimulation of acyl transferase activity by concanavalin A, an early response in lymphocyte activation, was entirely abolished in the presence of delta9-THC.