Three hypolipidemic drugs increase hepatic palmitoyl-coenzyme A oxidation in the rat

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Science  05 Aug 1977:
Vol. 197, Issue 4303, pp. 580-581
DOI: 10.1126/science.195342


Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.