Porphyrin induction: equivalent effects of 5alphaH and 5betaH steroids in chick embryo liver cells

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Science  12 Aug 1977:
Vol. 197, Issue 4304, pp. 659-660
DOI: 10.1126/science.877578


The 5alphaH (A : B trans) and 5betaH (A : B cis) steroids are equipotent in inducing delta-aminolevulinic acid synthetase and porphyrin accumulation in chick embryo liver cells maintained in serum-free culture medium. Thus there is no specific steric requirement for porphyrin-inducing activity in steroids.