Interferon: an inducer of macrophage activation by polyanions

Science  12 Aug 1977:
Vol. 197, Issue 4304, pp. 674-676
DOI: 10.1126/science.877584


Purified mouse fibroblast interferon (IF) directly rendered resting macrophages tumoricidal. The physicochemical properties and species specificity of the stimulatory agent fall within the present definition of IF. Since a number of polyanions induce macrophage IF, the antitumor and antimicrobial activities may result from the ability of newly released IF to modify macrophage activity.