Toxicity of mild prenatal carbon monoxide exposure

Science  12 Aug 1977:
Vol. 197, Issue 4304, pp. 680-682
DOI: 10.1126/science.877585


Rats prenatally exposed to a low concentration of carbon monoxide which results in carboxyhemoglobin levels equivalent to those maintained by human cigarette smokers, show reduced birth weight and decreased weight gain. Neuro-behavioral and biochemical testing of the offspring reveals lower behavioral activity levels through the preweaning period, altered central catecholamine activity, and reduction in total brain protein at birth.