Differentiating limb tissue affects neurite growth in spinal cord cultures

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Science  26 Aug 1977:
Vol. 197, Issue 4306, pp. 899-900
DOI: 10.1126/science.302031


Limb bud mesenchyme enhances and directs the growth of tadpole spinal cord nerve fibers in tissue culture. This effect on elongating neurites may involve alterations in nerve-substratum interactions by the presence of undifferentiated target tissues. The relationship between nerve fibers and their potential innervation sites can explain directed nerve growth to the developing limb.