Reye's syndrome: patient serum alters mitochondrial function and morphology in vitro

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Science  26 Aug 1977:
Vol. 197, Issue 4306, pp. 908-910
DOI: 10.1126/science.887930


A direct relationship between a putative Reye's syndrome "serum factor" and generalized mitochondrial damage has been demonstrated in vitro. The clinical features of Reye's syndrome may be secondary to disrupted mitochondrial structure and a consequent impairment of energy-linked functions involving many organs.