Age-related changes in the hepatic endoplasmic reticulum: a quantitative analysis

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Science  02 Sep 1977:
Vol. 197, Issue 4307, pp. 1005-1008
DOI: 10.1126/science.887935


Morphometric analysis demonstrated a twofold increase in the surface area of the hepatic endoplasmic reticulum in Fischer 344 rats between 1 and 20 months of age, followed by a significant decrease in this parameter between 20 and 30 months. These changes are attributed to the smooth-surfaced endoplasmic reticulum, since neither the rough-surfaced variety nor the Golgi membranes underwent any significant change in surface area as a function of the age of the animal.