A method for detecting 8-methoxypsoralen in the ocular lens

Science  23 Sep 1977:
Vol. 197, Issue 4310, pp. 1287-1288
DOI: 10.1126/science.897669


The use of 8-methoxypsoralen for treating psoriasis could prove hazardous if this photosensitizing agent enters the ocular lens. Phosphorescence spectra of intact rat lenses reveal concentrations of 8-methoxypsoralen on the order 10(-5)M after intraperitoneal injection of 8-methoxypsoralen. There is evidence that this drug can function as a photosensitizing agent, enhancing ultraviolet-induced changes within the lens.