Expression of murine sarcoma virus genes in uninfected rat cells subjected to anaerobic sress

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Science  30 Sep 1977:
Vol. 197, Issue 4311, pp. 1371-1374
DOI: 10.1126/science.197602


Exposure of uninfected rat cells in tissue culture to anaerobic culture conditions induces transcription of RNA corresponding to the two principal constituents of rat-derived type-C sarcoma virus genomes: (i) those specific rat cell sequences present in the Kirsten and Harvey murine sarcoma virus genomes, and (ii) an endogenous type-C rat leukemia virus.