Striatal efferent fibers play a role in maintaining rotational behavior in the rat

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Science  07 Oct 1977:
Vol. 198, Issue 4312, pp. 62-64
DOI: 10.1126/science.897683


Rats in which ascending dopamine-containing neurons have been unilaterally destroyed by injections of 6-hydroxydopamine are known to rotate after being injected with apomorphine or L-dopa. The rotation is markedly reduced by either (i) ipsilateral electrocoagulations of the caudate-putamen or internal capsule or (ii) ipsilateral coronal knife cuts immediately rostral to the substantia nigra. Neostriatal efferent fibers, in particular the strionigral projection, appear to be required for the expression of this dopamine-dependent behavior.