Transplantable pancreatic carcinoma of the rat

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Science  07 Oct 1977:
Vol. 198, Issue 4312, pp. 78-80
DOI: 10.1126/science.897688


Pancreatic carcinoma, which developed in a male Fischer 344 rat fed 0.1% nafenopin for 20 months, is being successfully transplanted into weanling rats. The tumor cells contain variable numbers of zymogen granules, and the endoplasmic reticulum and the Golgi apparatus appear prominent. This transplantable tumor, which displays substantial amylase and lipase activity, should serve as a useful model system for immuno- and chemotherapeutic experiments, as well as for the study of synthesis, storage, and release of zymogen proteins in neoplastic cells.