Reports

Bovine protoporphyria: the first nonhuman model of this hereditary photosensitizing disease

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Science  14 Oct 1977:
Vol. 198, Issue 4313, pp. 199-201
DOI: 10.1126/science.905823

Abstract

Protoporphyria, a photosensitizing disease documented only in humans, was transmitted as a recessive trait to seven female calves. Cutaneous lesions were extensive, and erythrocyte and fecal protoporphyrin concentrations exceeded by far those of human protoporphyria. Average ferrochelatase activity was decreased to one-half of normal in the liver of carriers, and to about one-tenth of normal in liver, kidney, heart, spleen, lung, and marrow of protoporphyrics.

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