Diazepam maintenance of alcohol preference during alcohol withdrawal

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Science  21 Oct 1977:
Vol. 198, Issue 4314, pp. 307-309
DOI: 10.1126/science.561997


After forced intragastric intubation of alcohol, rats will show a greatly increased tendency to self-administer alcohol in a free-choice situation. Diazepam (Valium) dosage (5 milligrams per kilogram of body weight) during the period ow withdrawal serves to maintain undiminished such alcohol self-administration. Without such diazepam dosage the tendency to self-administer alcohol returns to control levels.