Erythrocyte lipids in heterozygous carriers of duchenne muscular dystrophy

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Science  21 Oct 1977:
Vol. 198, Issue 4314, pp. 309-310
DOI: 10.1126/science.910129


Erythrocyte membranes from heterozygous carriers of Duchenne muscular dystrophy exhibit a diminished amount of palmitoleic acid when compared to membranes from normal subjects. A similar, but more variable, diminution is observed in the case of patients with this disorder. The change in fatty acid composition appears related to a low membrane triglyceride content and may provide both a possible technique for carrier detection and a clue regarding pathogenesis.