Unilateral nephrectomy: effect on survival in NZB/NZW mice

Science  04 Nov 1977:
Vol. 198, Issue 4316, pp. 511-513
DOI: 10.1126/science.143718


Male F1 New Zealand Black X New Zealand White mice, which spontaneously develop immune complex renal disease, underwent unilateral nephrectomy at 3 months of age and were compared with sham-operated controls. At 12 months of age only 24% of mice with a single kidney were alive, while 85% of sham-operated controls survived to the same age. Unilaterally nephrectomized mice had more severe renal histologic changes, as shown by light and immunofluorescence microscopy.