Veatchine: Coexistence of Epimers in a Crystal Structure

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Science  18 Nov 1977:
Vol. 198, Issue 4318, pp. 726-727
DOI: 10.1126/science.198.4318.726


An x-ray crystal structure determination of veatchine, a C20-diterpenoid alkaloid, reveals the coexistence of molecules which differ in configuration at one of seven asymmetric carbon atoms. This disorder between epimers demonstrates the stability of both forms, and accounts for the doubling of certain peaks in the magnetic resonance spectra of this and related alkaloids.